Gout - Symptoms, Diet, Medication and Treatments of Gout

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2011-08-26T23:32:00.003-07:00

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Baliku-balimu.info

2011-06-13T00:49:00.001-07:00

Baliku-Balimu.info

Travel Blog tentang wisata Bali. Berisi tentang tempat-tempat menarik dan wisata Bali. Tips-tips hemat berwisata ke Bali. Wisata Badung, Denpasar, Tabanan, Gianyar, Bangli, Karangasem, Singaraja, Klungkung dan Jembrana.

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Something Blue in Bali and Indonesia

2011-05-30T20:20:00.001-07:00

Somethingblue.us

Something Blue in Bali, Indonesia and Beyond. Travel tips and interesting places in Bali, Indonesia and Beyond. Bali Beach, Indonesia Beach, southeast Asia and interesting places in the world. Enjoy all info in this site..

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2011-04-20T19:28:00.000-07:00

Novel Therapies Such as Krystexxa, Uloric, Adenuric and Colcrys to Drive Gout Therapeutics Market

2011-04-18T18:58:00.000-07:00

ROCKVILLE, MD--(Marketwire - April 12, 2011) - MarketResearch.com has announced the addition of GBI Research's new report "Gout Therapeutics Market to 2017- Entry of Novel Therapies such as Krystexxa, Uloric, Adenuric and Colcrys to Drive Market" to their collection of Pharmaceuticals market reports.

The global gout therapeutics market is a fast growing market. In 2010, the global gout therapeutics market was worth $542.6m in terms of revenue, which is forecast to grow to $1,561.3m by 2017, showing a growth rate of 16.3% between 2010 and 2017. The prevalence of gout has been increasing continuously since 2002. Consequently, the gout therapeutics market has been growing at a rapid pace over the years, and is expected to accelerate in the coming years. Furthermore, the launch of expected blockbuster drugs such as TMX 67 and Krystexxa, along with the presence of a few promising biologics in the late drug development stage, would drive this growth. As a result, the market will continue to remain fast growing, thereby attracting major pharmaceutical companies to this therapy area.

The number of gout patients is increasing year on year, and currently there are only three approved drugs in the market - Colcrys (colchicine), TMX 67 (febuxostat) and Krystexxa (pegloticase). Better efficacy and safety profiles of these drugs over generics such as non-steroidal anti inflammatory drugs (NSAID), corticosteroids, allopurinol and probenecid create a remarkable scope for gout therapeutics in the future. There is a sharp increase in the number of patients who are unable to respond to the conventional treatment for chronic gout. Therefore Krystexxa could target a more focused patient pool, refractory to conventional allopurinol therapy, thereby providing a better alternative biologic treatment option.

In the past five to six years many pharmaceutical companies have improved their product profiles with respect to the musculoskeletal disorders therapeutics market. This is due to strategic deals with the aim of introducing new products with better efficacy and safety profiles into the market. Many pharmaceutical companies have either acquired or signed licensing deals with companies possessing potential products for the gout therapeutics market. The acquisitions of worldwide rights of Pegsiticase from EnzymeRx by 3SBio, and the pharmaceutical products portfolio from AstraZeneca by BioPhausia, have been the major acquisitions in the gout therapeutics market.

Under licensing agreements the highest valued deal was a licensing agreement between XOMA Ltd and Les Laboratoires Servier to develop and commercialize XOMA 052. In addition, Menarini Group has entered into a licensing agreement with Ipsen to market Adenuric (febuxostat) in 41 countries including Europe, Russia, and countries west of Russia. These strategic consolidations have allowed pharmaceutical companies such as Ipsen Pharmaceuticals, Menarini Group, 3SBio and XOMA Ltd to enter the market.

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2011-04-16T02:08:00.001-07:00

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Gout attack? What to do

2011-04-15T04:46:00.001-07:00

TWO weeks ago we took a brief look at the broad condition commonly known as arthritis. More than 100 types of arthritis have been identified, all of which result from different causes and respond to different treatment methods.

Today we’re going to delve further into the world of gout, a type of arthritis that can be greatly influenced by our diet and lifestyle habits.

Gout is associated with a sudden onset of very painful inflamed joints. After an initial attack, patients may be free of symptoms for months or even years. It is also possible though that some gout sufferers experience more frequent attacks and may eventually experience permanent joint damage. The most common joints to be affected are the knee, ankle, big toe, elbow, wrist and fingers.

The pain and inflammation experienced during a gout attack is due to the deposit of uric acid crystals in particular joints. High uric acid levels in the blood stream increases the likelihood of crystals forming, and therefore the main aim is to lower these levels. Uric acid is formed by the breakdown of purines which are chemicals made in the body and are also found in many foods.

Medical treatment of gout can be very effective with a wide variety of medications available. In addition to medications, dietary and lifestyle changes can be effective in preventing recurring bouts of gout and reducing the frequency of attacks.

Research has shown that gout is much more prevalent in people who eat a small amount of vegetables and a large amount of meat, including fish and chicken. This is most likely due to the fact that uric acid levels are raised by eating large amounts of meat. Drinking alcohol, in particular beer, and being overweight also raise uric acid levels.

Let’s look at how one can adapt ones diet to lower the incidence of gout.

• Drink lots of water. This is most important as it allows the body to flush out excess acid building up in the body. Intentionally increase your intake of non-caffeine fluids during the day , for example rooibos tea, herbal teas, water flavoured with mint or lemon.

• Avoid foods high in purines. These mainly include beer and animal products (such as bacon, beef, pork, lamb, liver, kidney, and even sardines and anchovies). Try to reduce your servings of meat by choosing smaller pieces of chicken, steak or chops at your main meal and include more meat-free lunches in the week.

• Increase your intake of vegetables and fruits. This helps to reduce the general acidity in your body and lowers the uric acid content.

• If you are overweight, make a conscious effort to lose weight. This will lower uric acid levels and simply place less strain on your joints.

• Reduce alcohol intake (especially beer) to no more than one drink per day and try to achieve one to two alcohol-free days per week. Drinking wine instead of beer on the occasions when you do drink will also prevent an increase in uric acid.

• Use low-fat milk daily. A recent study shows that drinking one cup of low-fat milk daily is associated with lowering uric acid levels and reducing the incidence of gout.

Next time we will continue with this broad topic of arthritis by taking a closer look at the plethora of supplements available for treating the various forms of arthritis. We’ll investigate which ones are backed by science with proven benefit, and which ones are too good to be true.

Tests and diagnosis

2008-08-03T10:39:00.000-07:00

When to seek medical advice

If you experience sudden, intense pain in a joint, call your doctor. Gout that goes untreated can lead to worsening pain and joint damage.

Seek medical care immediately if you have a fever and a joint is hot and inflamed, which can be a sign of infection.

Tests and diagnosis

Tests to help diagnose gout may include:

Joint fluid test. Your doctor may use a needle to draw fluid from your affected joint. When examined under the microscope, your joint fluid may reveal urate crystals.
Blood test. Your doctor may recommend a blood test to measure the uric acid level in your blood. Blood test results can be misleading, though. Some people have high uric acid levels, but never experience gout. And some people have signs and symptoms of gout, but don't have unusual levels of uric acid in their blood.

Complications

People with gout can develop more-severe conditions, such as:

Recurrent gout. Some people may never experience gout signs and symptoms again. But others may experience gout several times each year. Medications may help prevent gout attacks in people with recurrent gout.
Advanced gout. Untreated gout may cause deposits of urate crystals to form under the skin in nodules called tophi (TOE-fi). Tophi usually aren't painful, but they can become swollen and tender during gout attacks.
Kidney stones. Urate crystals may collect in the urinary tract of people with gout, causing kidney stones. Medications can help reduce the risk of kidney stones.

GOUT

2008-08-03T10:33:00.000-07:00

Gout is a complex disorder that can affect anyone. Men are more likely to get gout than women are, but women become increasingly susceptible to gout after menopause.

Fortunately, gout is treatable, and there are ways to reduce the risk that gout will recur.

Risk factors

You're more likely to develop gout if you have high levels of uric acid in your body. Factors that increase the uric acid level in your body include:

Lifestyle factors. Choices you make in your everyday life may increase your risk of gout. Excessive alcohol use — generally more than two drinks a day for men and more than one for women — increases the risk of gout.
Medical conditions. Certain diseases and conditions make it more likely that you'll develop gout. These include untreated high blood pressure (hypertension) and chronic conditions, such as diabetes, high levels of fat and cholesterol in the blood (hyperlipidemia), and narrowing of the arteries (arteriosclerosis).
Certain medications. The use of thiazide diuretics — commonly used to treat hypertension — and low-dose aspirin also can increase uric acid levels. So can the use of anti-rejection drugs prescribed for people who have undergone an organ transplant.
Family history of gout. If other members of your family have had gout, you're more likely to develop the disease.
Age and sex. Gout occurs more often in men than it does in women, primarily because women tend to have lower uric acid levels than men do. After menopause, however, women's uric acid levels approach those of men. Men also are more likely to develop gout earlier — usually between the ages of 40 and 50 — whereas women generally develop signs and symptoms after menopause.

2008-07-20T06:19:00.000-07:00

Technorati Profile

GOUT DIET

2008-07-02T09:58:00.001-07:00

Gout is a very painful form of arthritis caused by too much uric acid buildup in the body. Gout can cause a painful swelling in your joints, particularly and especially the big toe. The big toe appears to be a favorite target of gout. Most people experience an outbreak of gout when they are awakened by a large, red swollen toe. You can have large amounts of uric acid in the blood and never experience an outbreak.

So how can we cure gout, or how can we minimize gout's symptoms? Let's start with the basic cause, uric acid. How can we lower the amount of uric acid in the body? We can do this two ways. The first way is to make sure we don't ingest foods that will raise our level of uric acid (high level purines). The second way is to allow the body to excrete the excess uric acid, or somehow stimulate the removal of uric acid from the body. Let's look a bit at foods.

Can the wrong foods cause gout? The simple answer is that certain foods will elevate the uric acid content in your blood which can bring on an attack. Foods that contain high levels of purines should be avoided. Surprisingly, foods that are high in purines come from all food groups. Even some vegetables are high in purines. Certain meats are high in purines. Examples include liver, kidneys, and sweetbreads. Seafood that contains high levels of purines include shellfish. Lobsters, shrimp, sardines and anchovies are high in purines and should be avoided. Vegetables that have high levels of purines include asparagus, legumes, beans and peanuts, cauliflower and spinach. Another thing to avoid is drinking alcohol, particularly beer. Beer is high in purines and should be consumed in moderation if at all.

We started our discussion of how to cure gout by limiting the foods that can cause gout. Our second approach to curing gout is assisting the body to excrete more uric acid. How can we do this? The body is capable of excreting a certain amount of uric acid. When we help by ingesting foods that are low in purines, the body can catch up and lower the uric acid level in the body. It is important to drink lots of water during this process. Drinking lots of water helps dilute the uric acid in the body and helps the kidneys excrete it. Vitamin C can help release the uric acid that is in the body's tissues. Care must be taken to take low doses throughout the day to prevent a spike in uric acid. Flavonoids can also help to reduce uric acid levels. Blueberries and cherries contain high levels of flavonoids and can help the body reduce the uric acid level.

We may not be able to cure gout, but as we've already seen, we can alleviate the symptoms by reducing the uric acid level in the body. To recap, we should eat foods low in purines, refrain from consuming alcohol, drink lots of water, and take Vitamin C and blueberry and/or cherry extracts.

The Medications og Gout

2008-05-24T02:11:00.000-07:00

Medication treatment for gout may be done in two separate stages.

First, the pain, swelling, redness, and warmth (inflammation) during an attack of gout is treated until the symptoms have gone away.
Second, after the inflammation has subsided (2 to 4 weeks), other medications may be used to reduce the uric acid level in the blood and reduce the frequency of future attacks.

Medications to lower uric acid levels are not given until a gout attack is over. Starting these medications during a gout attack can cause movement of uric acid stored elsewhere in the body, which can make the gout attack worse.

Long-term medication treatment depends on how high your uric acid levels are and how likely other gout attacks are. In general, the higher the uric acid levels and the more frequent the attacks, the more likely it is that long-term medication treatment will help.

During a gout attack

You may already be taking a medication to lower uric acid levels in the blood at the time of an attack. If so, you should continue taking your medication, even during an attack.

If you have been prescribed a medication to lower uric acid levels (probenecid or allopurinol) and have not been taking the medication, it is more likely that another gout attack will occur. Do not start taking the medication during an attack. Medications that control the uric acid levels in your blood can also make the uric acids stored elsewhere in the body move into your bloodstream. Starting these medications while you are having a gout attack can make your attack much worse.

Medication Choices

Medication treatment for gout usually involves some combination of:

Short-term treatment, using medications that relieve pain and reduce inflammation during an acute attack or prevent a recurrence of an acute attack. These medications may include:

Nonsteroidal anti-inflammatory drugs (NSAIDs), except for aspirin, which should never be used to relieve pain during a gout attack. Aspirin may abruptly change uric acid levels in the blood and may make the attack worse.
Colchicine, which may also be used for long-term treatment.
Corticosteroids, which may be given in pills or by a shot for cases of gout that do not respond to NSAIDs or colchicines. They may also be given to people who cannot take NSAIDs for other reasons, such as those with chronic kidney failure, heart failure, gastrointestinal bleeding or those using a blood-thinner, such as warfarin.

Long-term treatment, using medications to lower uric acid levels in the blood, which can reduce the frequency and severity of gout attacks in the future. This may include:

Uricosuric agents to increase elimination of uric acid by the kidneys.
Allopurinol to decrease production of uric acid by the body.
Colchicine to prevent flare-ups during the first months that you are taking uric acid-lowering medications.

What To Think About

Relief from symptoms in a gout attack often occurs within 24 hours if treatment is started immediately.
During a gout attack, your health professional will prescribe a maximum daily dose of one or more medications used for short-term treatment to stop the attack quickly. Doses are then reduced as the symptoms go away.
NSAIDs other than aspirin are used most often to treat a gout attack.
Because all medications that lower uric acid levels in the blood have associated risks, an accurate diagnosis of gout is necessary before they are used.
Aspirin should never be used to relieve pain during a gout attack because it slows the elimination of uric acid and can raise uric acid levels further.
Gout attacks in older people can take longer to go away.

Cure Gout by Eating the Right Foods and Supplements

2008-05-22T09:14:00.000-07:00

Foods That Cause Gout

2008-05-20T23:47:00.000-07:00

The foods that cause gout are some of our favorites. Gout can also be controlled through dietary changes. When someone with poor kidney health goes on a high protein diet, uric acid crystals can form in joints and kidneys – called gout – and in other parts of the body – called acidosis. The symptoms of gout come and go. The most famous victim of gout is King Henry VIII(1491-1547). Gout has these unmistakable symptoms: Sudden, intense pain, beginning in the big toe, ankle, heel, or instep. Gout is a form of arthritis and it is triggered by elevated levels of uric acid in the blood. However, as a gout sufferer it is vitally important to keep your fluid intake up. The main cause of gout is the accumulation and deposition of uric crystals at the level of the joints and adjacent soft tissues. It is important to note that that gout diets alone can't overcome the disease completely. Thus, the intake of sweet cherries can also ease recurrent gout pain. Exercise is the fifth way to lower risk of gout attacks. If no treatment is administered within the first 12 hours, combating gout becomes near to impossible. A gout diet should completely exclude organ meats (heart, liver, kidneys), and seafood (shrimps, mussels), as they are very rich in purines. Unfermented grape juice and honey is an old folk remedy that many claim can reduce the swelling and pain associated with gout. Middle-aged males are the most prevalent victims of gout and is hereditary in nature. There are people with higher levels of uric acid in their body due to certain medicines they are consuming or certain physical conditionsSome MedicinesListed are some drugs, which might lead to hyperuricemia since they reduce the body"s ability to remove uric acid:Diuretics - taken to eliminate excess fluid from the bodySalicvlates - an anti-inflammatory drugs made from salicylic acidNiacin - also known as nicotinic acidCyclosporine - an immunosuppressantLevodopa - taken to treat Parkinson"s diseaseIf you wish to have more information on Gout Causes and the Different Kinds of Gout Treatment, please visit gout. There are a number of risk factors that are related to the development of hyperuricemia and gout:Gender and age are related to the risk of developing gout; it is found to be more common in men than in women and more common in adults than in children. Crystal deposits can cause also a condition known as false gout but in this case the composition of crystals is calcium phosphate dehydrate and not uric acid. Now that you know the role weight plays in gout risk, it's time to take a look at the right way of losing weight to prevent gout, and the wrong way. Experts believe that the anthocyanins found in low purine juice are what relieves the symptoms of gout as the substance lowers urate levels in the blood. If you are overweight, it is imperative that you know there is a ideal method to utilise when it comes to shedding pounds for gout prevention. There are a number of ways to treat gout, but if you want to avoid medication then why not try these gout pain natural remedies. Dark berries, such as cherries, blueberries, strawberries and cranberries have been shown to contain a chemical that helps the body process and get rid of uric acid and should be a part of a diet for gout. Medical TreatmentThere are many medications usually prescribed for gout treatment. Gout is caused by deposits of uric acid crystals in the joint. Although there are different medications to treat gout, there are also different non-drug treatments such as tissue salts which can provide relief. What causes gout is very simply an over abundance of uric acid. People who are at risk of developing gout are advised to limit the intake of meats such as pork, beef, lamb and duck. Recent findings have revealed the fact that low-fat dairy products have an important role in both preventing and overcoming the undesirable effects of gout. Keeping a cold compress pack in the freezer makes this an easy task when gout strikes. Avoiding alcohol (especially beer) and the refined sugars, sucrose and fructose will also help with gout. If is vital that gout patients understand their situation and seek help to prevent further occurrences of gout attacks, or at least to lessen the severity of the attacks such that reduced pain is experienced.

Gout Remedies Purple thoroughwort, also called Joe - Pye Weed is another of the gout remedies that some say helps in treating gout; it flushes uric acid quickly out of the body, but extended use can be detrimental to the kidneys. Gout remedies begin with cutting excessive purines out of the diet. A diet that is part of one of the most effective gout remedies should rely on complex carbohydrates for a majority of calories, and animal fats should be heavily restricted.

Gout Symptoms Cherry juice is not a drug and therefore has not been submitted to the clinical trials that medications have, however, many gout sufferers have found relief from their gout symptoms while drinking or taking cherry juice or extract. Cherry Juice1950 was the year that cherries were discovered to bring relief from gout symptoms. The second way of combating gout symptoms is drinking water. It is these sharp, rough edged crystals that cause gout symptoms; a hot, red, swollen, stiff and very painful joint. The fourth way to lower gout symptoms is to cut out the alcohol. The truth of the matter is that if a person is overweight it is almost certain to exacerbate gout symptoms due to the waste products that are broken down into uric acid.

Gout Diets It is important to note that that gout diets alone can't overcome the disease completely. To prevent gout, it is helpful to know the foods that cause gout.

The Symptoms Of Gout

2008-05-20T23:37:00.000-07:00

Gout is one of the most controllable diseases and should be treated as a serious health problem by anyone exhibiting the symptoms of gout. Uric acid is normally passed from the body by the urine. Sometimes, however, the body makes more uric acid than the kidneys can deal with. When this occurs, gout may develop.

Gout can cause a great deal of pain as it causes the uric acid to accumulate in areas of the body in which blood flow may not be as great as in other parts of the body. The joints are such a place and that is why the pain of gout manifests itself in the joints. This is a disabling disease that affects many people and it is a disease that can be controlled in many cases. We are all liable to develop gout at any time because the body makes about as much uric acid as can be dealt with at any given time. Many times, gout develops as a result of outside interference such as overeating or overdrinking. Infections can trigger gout. Since we can or should be able to control eating and drinking, we can control gout.

The main symptom of gout is severe pain in the joints. The elbows and knees are a typical location for gout to develop as are the knuckles of the hands and the big toe. Most of the time, a person has no warning of the gout attack. Some people claim to notice small twinges of pain that serve as a warning. The pain may develop in just a few hours and can leave a victim with swollen and tender joints. A weak fever of 101degrees of less may be experienced. Most initial attacks of gout affect only one joint and may not attack again for years. In any case, let your doctor know and he can not only track the disease, but prescibe some painkiller for you. You should not use aspirin as it slows down the excretion of uric acid and thus could prolong or worsen the gout attack.

Learn to controll your drinking and overeating habits. These can lead to further attacks. Such foods as red meat or sardines can be a contributor to the symptoms of gout.

CAUSES OF GOUT

2008-05-19T22:37:00.000-07:00

An ancient disease, gout is a chronic type of inflammatory arthritis that causes immediate attacks of pain, tenderness, redness, warmth and swelling in some joints. Usually, the joints in the big toe are affected, but gout can also affect the instep, ankles, heels, knees, wrists, fingers and elbows.

Once believed to be the result of gluttony, gout is now known to affect people from all walks of life and often the disease is inherited. Less than one in ten women will develop gout. About 500,000 people have gout in the United States, with most being men between the ages of 30 and 60. Gout accounts for about 5 percent of all cases of arthritis.

Gout is caused when there is over production of uric acid in normal purine metabolism in the body. Genetics can play a role in who develops gout. It can also occur as a complication of other conditions. Some people inherit the inability to process uric acid and lose it in the urine. High blood levels of uric acid in turn causes sodium monourate crystals to collect in the joint fluid and joint coverings leading to gout, a painful stiff swollen joint.

There are many reasons why an episode of gout will appear, including drinking too much alcohol or eating certain kinds of food rich in purines such as seafood, beans, sweetbreads, gravies and anchovies.

Other potential triggers of gout include:

Surgery
Stress
Crash diets
Sudden, severe illness
Chemotherapy
Joint injury
High blood pressure
Excessive exercise.